{"id":3364,"date":"2026-03-31T17:07:59","date_gmt":"2026-03-31T17:07:59","guid":{"rendered":"https:\/\/odakhaber.site\/?p=3364"},"modified":"2026-03-31T17:07:59","modified_gmt":"2026-03-31T17:07:59","slug":"bilim-dunyasinda-sarsici-kesif-dnanin-dansi-kanserin-gizli-sebebi-olabilir","status":"publish","type":"post","link":"https:\/\/odakhaber.site\/?p=3364","title":{"rendered":"Bilim D\u00fcnyas\u0131nda Sars\u0131c\u0131 Ke\u015fif: DNA\u2019n\u0131n Dans\u0131 Kanserin Gizli Sebebi Olabilir"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Y\u0131llard\u0131r h\u00fccre \u00e7ekirde\u011finde sabit bir k\u00fct\u00fcphane gibi durdu\u011fu d\u00fc\u015f\u00fcn\u00fclen DNA\u2019n\u0131n, asl\u0131nda s\u00fcrekli hareket halinde oldu\u011fu ortaya \u00e7\u0131kt\u0131.\u00a0Salk Enstit\u00fcs\u00fc\u00a0ara\u015ft\u0131rmac\u0131lar\u0131 taraf\u0131ndan ger\u00e7ekle\u015ftirilen ve\u00a0<em>Nature Genetics<\/em>\u00a0dergisinde yay\u0131mlanan \u00e7al\u0131\u015fma, genetik kodun durmadan &#8220;katlanma ve a\u00e7\u0131lma&#8221; refleksi g\u00f6steren dinamik bir yap\u0131da oldu\u011funu kan\u0131tlad\u0131.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Molek\u00fcler Makineler \u0130\u015f Ba\u015f\u0131nda<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Yakla\u015f\u0131k\u00a0alt\u0131 milyar baz \u00e7iftinden\u00a0olu\u015fan insan genomunun mikroskobik bir h\u00fccre \u00e7ekirde\u011fine s\u0131\u011fmas\u0131 i\u00e7in karma\u015f\u0131k halkalar halinde katlanmas\u0131 gerekiyor. Ancak bu i\u015flem bir kez ger\u00e7ekle\u015fip bitmiyor.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Akt\u00f6rler:<\/strong>\u00a0<strong>Cohesin<\/strong>\u00a0ve\u00a0NIPBL\u00a0ad\u0131 verilen \u00f6zel proteinler, birer &#8220;molek\u00fcler makine&#8221; gibi \u00e7al\u0131\u015f\u0131yor.<\/li>\n\n\n\n<li><strong>\u0130\u015flev:<\/strong>\u00a0Bu proteinler DNA \u00fczerinde s\u00fcrekli yeni d\u00f6ng\u00fcler olu\u015fturup bunlar\u0131 bozarak genomu bir a\u00e7\u0131lma ve yeniden katlanma d\u00f6ng\u00fcs\u00fc i\u00e7inde tutuyor.<\/li>\n\n\n\n<li><strong>Karar Mekanizmas\u0131:<\/strong>\u00a0Salk Enstit\u00fcs\u00fc\u2019nden\u00a0Do\u00e7ent Jesse Dixon, bu hareketlili\u011fin hangi genlerin &#8220;a\u00e7\u0131k&#8221; veya &#8220;kapal\u0131&#8221; kalaca\u011f\u0131n\u0131 do\u011frudan belirledi\u011fini ifade ediyor.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">H\u00fccre Kimli\u011fi ve Hareketlilik \u0130li\u015fkisi<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ara\u015ft\u0131rma, DNA\u2019daki bu hareketlili\u011fin h\u00fccre t\u00fcr\u00fcne g\u00f6re \u00f6zelle\u015fti\u011fini saptad\u0131. \u00d6rne\u011fin; kalp h\u00fccrelerinde kalbe dair genler, n\u00f6ronlarda ise beyinle ilgili genler \u00e7ok daha h\u0131zl\u0131 ve dinamik bir bi\u00e7imde katlan\u0131yor.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">&#8220;Bu s\u00fcrekli hareket, h\u00fccrenin kim oldu\u011funu hat\u0131rlamas\u0131na yard\u0131mc\u0131 oluyor.&#8221; \u2014\u00a0Dr. Tessa Popay (\u00c7al\u0131\u015fman\u0131n ba\u015fyazar\u0131)<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">Bilim insanlar\u0131na g\u00f6re, e\u011fer bu dinamik yap\u0131 durur veya ritmi bozulursa, h\u00fccre g\u00f6revlerini &#8220;unutabiliyor.&#8221; Bu durum ise kontrols\u00fcz h\u00fccre \u00e7o\u011falmas\u0131na, yani\u00a0kanser olu\u015fumuna\u00a0zemin haz\u0131rl\u0131yor.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">Kanser Tedavisinde Paradigma De\u011fi\u015fimi<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Bu ke\u015fif, kanser ara\u015ft\u0131rmalar\u0131nda tamamen yeni bir bak\u0131\u015f a\u00e7\u0131s\u0131 sunuyor. Mevcut tedavilerin \u00e7o\u011fu genetik mutasyonlara (kodun kendisindeki hatalara) odaklan\u0131rken, bu \u00e7al\u0131\u015fma kod sa\u011flam olsa bile sadece&nbsp;<strong>katlanma bi\u00e7imindeki bir hatan\u0131n<\/strong>&nbsp;hastal\u0131\u011f\u0131 tetikleyebilece\u011fini g\u00f6steriyor.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td>Geleneksel Bak\u0131\u015f<\/td><td>Yeni Ke\u015fif<\/td><\/tr><\/thead><tbody><tr><td>Odak: Genetik kodun kendisindeki (mutasyon) hatalar.<\/td><td>Odak: DNA&#8217;n\u0131n hareket ve katlanma bi\u00e7imindeki hatalar.<\/td><\/tr><tr><td>Yakla\u015f\u0131m: Bozuk genleri d\u00fczeltmek veya yok etmek.<\/td><td>Yakla\u015f\u0131m: Hatal\u0131 katlanma mekanizmalar\u0131n\u0131 ve h\u00fccre kimli\u011fini d\u00fczeltmek.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Dixon ve ekibine g\u00f6re<\/strong>, kanser bu katlanma mekanizmalar\u0131n\u0131 suistimal ederek h\u00fccre kimli\u011fini manip\u00fcle ediyor. Bu dinamiklerin \u00e7\u00f6z\u00fclmesi, gelecekte sadece genleri de\u011fil, DNA\u2019n\u0131n hatal\u0131 hareket bi\u00e7imlerini de d\u00fczeltebilecek devrimsel tedavi y\u00f6ntemlerinin \u00f6n\u00fcn\u00fc a\u00e7abilir.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed is-provider-objektif-haber wp-block-embed-objektif-haber\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"n7Kvun3oZ5\"><a href=\"https:\/\/objektif.site\/2026\/03\/31\/bilim-insanlari-dnanin-hareket-ettigini-kesfetti-kanserin-sebebi-olabilir\/\">Bilim \u0130nsanlar\u0131 DNA\u2019n\u0131n \u2018Hareket Etti\u011fini\u2019 Ke\u015ffetti: Kanserin Sebebi Olabilir<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;Bilim \u0130nsanlar\u0131 DNA\u2019n\u0131n \u2018Hareket Etti\u011fini\u2019 Ke\u015ffetti: Kanserin Sebebi Olabilir&#8221; &#8212; Objektif Haber\" src=\"https:\/\/objektif.site\/2026\/03\/31\/bilim-insanlari-dnanin-hareket-ettigini-kesfetti-kanserin-sebebi-olabilir\/embed\/#?secret=iPV7THIu4i#?secret=n7Kvun3oZ5\" data-secret=\"n7Kvun3oZ5\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Y\u0131llard\u0131r h\u00fccre \u00e7ekirde\u011finde sabit bir k\u00fct\u00fcphane gibi durdu\u011fu d\u00fc\u015f\u00fcn\u00fclen DNA\u2019n\u0131n, asl\u0131nda s\u00fcrekli hareket halinde oldu\u011fu ortaya \u00e7\u0131kt\u0131.\u00a0Salk Enstit\u00fcs\u00fc\u00a0ara\u015ft\u0131rmac\u0131lar\u0131 taraf\u0131ndan ger\u00e7ekle\u015ftirilen ve\u00a0Nature Genetics\u00a0dergisinde yay\u0131mlanan \u00e7al\u0131\u015fma, genetik kodun durmadan &#8220;katlanma ve a\u00e7\u0131lma&#8221; refleksi g\u00f6steren dinamik bir yap\u0131da oldu\u011funu kan\u0131tlad\u0131. Molek\u00fcler Makineler \u0130\u015f Ba\u015f\u0131nda Yakla\u015f\u0131k\u00a0alt\u0131 milyar baz \u00e7iftinden\u00a0olu\u015fan insan genomunun mikroskobik bir h\u00fccre \u00e7ekirde\u011fine s\u0131\u011fmas\u0131 i\u00e7in karma\u015f\u0131k halkalar [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":3365,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[39],"tags":[],"class_list":["post-3364","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik-haberleri"],"jetpack_featured_media_url":"https:\/\/odakhaber.site\/wp-content\/uploads\/2026\/03\/dunya-kansere-karsi-savasi-kazaniyor-lf2f.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/posts\/3364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/odakhaber.site\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3364"}],"version-history":[{"count":1,"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/posts\/3364\/revisions"}],"predecessor-version":[{"id":3366,"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/posts\/3364\/revisions\/3366"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/media\/3365"}],"wp:attachment":[{"href":"https:\/\/odakhaber.site\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/odakhaber.site\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/odakhaber.site\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}