{"id":5267,"date":"2026-05-02T18:35:08","date_gmt":"2026-05-02T18:35:08","guid":{"rendered":"https:\/\/odakhaber.site\/?p=5267"},"modified":"2026-05-02T18:35:08","modified_gmt":"2026-05-02T18:35:08","slug":"obezite-tedavisinde-yapay-zeka-devrimi-ozempice-dogal-ve-yan-etkisiz-alternatif-yolda","status":"publish","type":"post","link":"https:\/\/odakhaber.site\/?p=5267","title":{"rendered":"Obezite Tedavisinde Yapay Zeka Devrimi: Ozempic\u2019e Do\u011fal ve Yan Etkisiz Alternatif Yolda"},"content":{"rendered":"\n

Stanford \u00dcniversitesi T\u0131p Fak\u00fcltesi\u2019nde y\u00fcr\u00fct\u00fclen \u00e7\u0131\u011f\u0131r a\u00e7\u0131c\u0131 bir ara\u015ft\u0131rma, obeziteyle m\u00fccadelede yeni bir d\u00f6nemin kap\u0131s\u0131n\u0131 aral\u0131yor. Yapay zeka kullan\u0131larak ke\u015ffedilen BRP<\/strong> adl\u0131 molek\u00fcl, mevcut zay\u0131flama ila\u00e7lar\u0131n\u0131n en b\u00fcy\u00fck sorunu olan yan etkileri ortadan kald\u0131rarak kilo kayb\u0131 sa\u011flama potansiyeli ta\u015f\u0131yor.<\/p>\n\n\n\n

Hipotalamusu Hedefleyen Yeni Mekanizma<\/h3>\n\n\n\n

G\u00fcn\u00fcm\u00fczde pop\u00fcler olan Ozempic, Wegovy ve Mounjaro gibi ila\u00e7lar, i\u015ftah\u0131 bask\u0131layan GLP-1 hormonunu taklit ederek \u00e7al\u0131\u015f\u0131yor. Ancak bu ila\u00e7lar esas olarak beynin arka k\u0131sm\u0131n\u0131 etkiledi\u011fi i\u00e7in pek \u00e7ok hastada mide bulant\u0131s\u0131, kusma ve kar\u0131n a\u011fr\u0131s\u0131 gibi \u015fikayetlere yol a\u00e7\u0131yor.<\/p>\n\n\n\n

Yeni ke\u015ffedilen 12 amino asitlik BRP molek\u00fcl\u00fc ise farkl\u0131 bir rota izliyor. Do\u011frudan i\u015ftah d\u00fczenleyici merkez olan hipotalamusu<\/strong> hedef alan bu molek\u00fcl, a\u00e7l\u0131k hissini buradan kontrol ediyor. Hayvanlar \u00fczerinde yap\u0131lan deneylerde, BRP\u2019nin sadece ya\u011f kayb\u0131 sa\u011flad\u0131\u011f\u0131 ve mevcut ila\u00e7lar\u0131n aksine kas kayb\u0131na yol a\u00e7mad\u0131\u011f\u0131 g\u00f6zlemlendi.<\/p>\n\n\n\n

“Peptide Predictor” ile 20 Bin Gen Tarand\u0131<\/h3>\n\n\n\n

BRP molek\u00fcl\u00fcn\u00fcn ke\u015ffi, “Peptide Predictor” ad\u0131 verilen \u00f6zel bir yapay zeka sistemi sayesinde ger\u00e7ekle\u015fti. Bilim insanlar\u0131 bu sistemle yakla\u015f\u0131k 20 bin insan genini tarayarak hormon benzeri 2 bin 683 potansiyel peptidi belirledi. Laboratuvar ortam\u0131nda test edilen 100 aday aras\u0131ndan BRP, en ba\u015far\u0131l\u0131 sonu\u00e7 veren molek\u00fcl olarak \u00f6ne \u00e7\u0131kt\u0131.<\/p>\n\n\n\n

Michigan \u00dcniversitesi’nden Randy J. Seeley, bu teknolojik ba\u015far\u0131y\u0131 \u015fu s\u00f6zlerle de\u011ferlendiriyor: \u201cBu kadar \u00e7ok say\u0131da peptidin tek tek incelenmesi ger\u00e7ekten etkileyici. \u00c7al\u0131\u015fmaya hayran kald\u0131m.\u201d<\/strong><\/p>\n\n\n\n

\u0130nsan Deneyleri ve Gelecek Beklentileri<\/h3>\n\n\n\n

Ara\u015ft\u0131rman\u0131n ba\u015f yazar\u0131 Katrin Svensson, molek\u00fcl\u00fc insan klinik deneylerine ta\u015f\u0131mak i\u00e7in haz\u0131rl\u0131klara ba\u015flarken, uzmanlar s\u00fcrecin uzun vadeli g\u00fcvenilirli\u011fi konusunda temkinli. Seeley, obezitenin kronik bir hastal\u0131k oldu\u011funu hat\u0131rlatarak, \u201cEn b\u00fcy\u00fck soru, bu molek\u00fcle dayal\u0131 bir ilac\u0131n uzun vadede yeterince g\u00fcvenli olup olmayaca\u011f\u0131\u201d<\/strong> uyar\u0131s\u0131nda bulunuyor.<\/p>\n\n\n\n

D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc verilerine g\u00f6re d\u00fcnyada bir milyardan fazla insan obezite ile m\u00fccadele ediyor ve bu say\u0131n\u0131n 2030\u2019a kadar iki kat\u0131na \u00e7\u0131kmas\u0131 bekleniyor. Dr. Giles Yeo, gelinen noktay\u0131 \u00e7arp\u0131c\u0131 bir tespitle \u00f6zetliyor:<\/p>\n\n\n\n

\n

\u201cBug\u00fcn d\u00fcnyada obeziteyle ya\u015fayan yakla\u015f\u0131k bir milyar insan var. Art\u0131k obezite nedeniyle hayat\u0131n\u0131 kaybedenlerin say\u0131s\u0131, k\u0131tl\u0131ktan \u00f6lenlerden daha fazla. \u0130nsanl\u0131k tarihinde ilk kez b\u00f6yle bir noktaday\u0131z. Bu nedenle ne kadar \u00e7ok tedavi se\u00e7ene\u011fi geli\u015ftirilirse, o kadar iyi.\u201d<\/strong><\/p>\n<\/blockquote>\n\n\n\n

BRP ba\u015far\u0131l\u0131 olsa bile, kalp-damar sa\u011fl\u0131\u011f\u0131na ek faydalar sunan mevcut GLP-1 ila\u00e7lar\u0131n\u0131n tamamen devre d\u0131\u015f\u0131 kalmas\u0131 beklenmiyor. Ancak yeni se\u00e7enekler, hastalar\u0131n kendileri i\u00e7in en uygun ve s\u00fcrd\u00fcr\u00fclebilir tedavi kombinasyonunu bulmalar\u0131na imkan tan\u0131yacak.<\/p>\n\n\n\n

https:\/\/gazeteoksijen.com\/saglik\/yapay-zeka-ile-gelen-kesif-dogada-bulunan-bir-monekul-ozempice-alternatif-olabilir-274195<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Stanford \u00dcniversitesi T\u0131p Fak\u00fcltesi\u2019nde y\u00fcr\u00fct\u00fclen \u00e7\u0131\u011f\u0131r a\u00e7\u0131c\u0131 bir ara\u015ft\u0131rma, obeziteyle m\u00fccadelede yeni bir d\u00f6nemin kap\u0131s\u0131n\u0131 aral\u0131yor. Yapay zeka kullan\u0131larak ke\u015ffedilen BRP adl\u0131 molek\u00fcl, mevcut zay\u0131flama ila\u00e7lar\u0131n\u0131n en b\u00fcy\u00fck sorunu olan yan etkileri ortadan kald\u0131rarak kilo kayb\u0131 sa\u011flama potansiyeli ta\u015f\u0131yor. Hipotalamusu Hedefleyen Yeni Mekanizma G\u00fcn\u00fcm\u00fczde pop\u00fcler olan Ozempic, Wegovy ve Mounjaro gibi ila\u00e7lar, i\u015ftah\u0131 bask\u0131layan GLP-1 […]<\/p>\n","protected":false},"author":5,"featured_media":5268,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[39],"tags":[],"class_list":["post-5267","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik-haberleri"],"jetpack_featured_media_url":"https:\/\/odakhaber.site\/wp-content\/uploads\/2026\/05\/ozempic-biyolojik-yasinizi-da-dusurebilir-pd4h.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/posts\/5267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/odakhaber.site\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5267"}],"version-history":[{"count":1,"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/posts\/5267\/revisions"}],"predecessor-version":[{"id":5269,"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/posts\/5267\/revisions\/5269"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/odakhaber.site\/index.php?rest_route=\/wp\/v2\/media\/5268"}],"wp:attachment":[{"href":"https:\/\/odakhaber.site\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/odakhaber.site\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/odakhaber.site\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}